Welcome
Systematic, Comprehensive, In depth and Strategic Consulting
Global, Prediction, Precision, Prevention, Personalized, Population and Policy
Speaking Engagement
Dr. Liu discussed unraveling interactions from Nucleotions from Nucleotides to Nutritional Landscapes and Beyond at PolyU,HongKong
Post on July 24, 2023
Dr. Liu discussed why patients with diabetes patients are more likely to have bad outcomes with COVID-19 at a virtual International COVID-19 and Diabetes Summit
Post on August 31, 2020
Our Past and Current Consulting Engagements
Building heart failure prediction model combining multi-omics with pathway and network methodologies.
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Building heart failure prediction model combining multi-omics with pathway and network methodologies.
Design/Analysis/Interpretation/Translation
China National Health and Biomonitor Program
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Building heart failure prediction model combining multi-omics with pathway and network methodologies.
Design/Analysis/Interpretation/Translation
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Design/Analysis/Interpretation/Translation
Whole Grains and Chronic Disease: A Self-Study Guide for Health Professionals
Whole Grains and Chronic Disease: A Self-Study Guide for Health Professionals
Dietary Carbohydrates in Human Nutrition/ Glycemic Index and Health/ Challenges in nutritional epidemiology of chronic diseases
Design/Analysis/Interpretation/Translation
Epidemiology of Global Cardiometabolic Health: Past, Present and Future
Whole Grains and Chronic Disease: A Self-Study Guide for Health Professionals
Epidemiology of Global Cardiometabolic Health: Past, Present and Future
Design/Analysis/Interpretation/Translation
SELECT-Trial (18-CS-IKES-8)
Whole Grains and Chronic Disease: A Self-Study Guide for Health Professionals
Epidemiology of Global Cardiometabolic Health: Past, Present and Future
Data and Safety Monitoring
Carbohydrate Nutrition in Relation to Obesity and Chronic Diseases
Carbohydrate Nutrition in Relation to Obesity and Chronic Diseases
Carbohydrate Nutrition in Relation to Obesity and Chronic Diseases
Design/Analysis/Interpretation/Translation
International Carbohydrate Quality Consortium
Carbohydrate Nutrition in Relation to Obesity and Chronic Diseases
Carbohydrate Nutrition in Relation to Obesity and Chronic Diseases
Support/summarize/disseminate
Original Reports Selected
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
This is the first comprehensive and systematic human biomonitoring study that established population reference ranges for 30 (essential and/or toxic elements) in a Brazilian population group.
Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake...
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
We analyzed diabetes-free participants from 10 cohorts in the NHLBI Trans-Omics for Precision Medicine (TOPMed) program to identify macronutrient GDIs across the genetic frequency spectrum associated with continuous glycemic traits in genetically and culturally diverse cohorts.
Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazi
Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women
The study aimed to determine the predictive value of circulating sex hormone-binding globulin (SHBG) levels for coronary heart disease (CHD) risk in both men and women, by investigating the association between SHBG and incident CHD in 128,322 men and 135,103 women free of CHD at baseline in the UK Biobank cohort.
Micronutrient Supplementation to Reduce Cardiovascular Risk
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women
This systematic review and meta-analysis of randomized controlled intervention trials emphasizes the significance of diverse micronutrient intake and balancing its benefits and risks in promoting and maintaining cardiovascular health across diverse populations.
Prenatal exposure to famine and the development of diabetes later in life CHNS 97-95
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
We aimed to determine the association between prenatal exposure to the Chinese famine of 1959–1962 and risk of diabetes by applying age well-controlled strategies.
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Demographic and clinical factors influence the metabolome. The discovery and validation of disease biomarkers are often challenged by potential confounding effects from such factors. To address this challenge, we investigated the magnitude of the correlation between serum and urine metabolites and demographic and clinical parameters in a well-characterized observational cohort of 444 post-menopausal women participating in the Women’s Health Initiative (WHI)
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
The age of natural menopause (ANM) was observationally associated with an increased risk of breast cancer, endometrial cancer, and ovarian cancer and with a decreased risk of lung cancer, coronary heart disease, ischemic stroke, fracture, osteoporosis, and Alzheimer's disease in the Women’s Health Initiative and UK Biobank; however, to address potential confounding by overall markers of health, a genetic instrument variable was used in Mendelian randomization to examine the causal effect of ANM on these adverse outcomes.
Examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age group
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
Among women with prior BSO, in those aged 70 years or older, CEE led to adverse effects during the treatment period, whereas women randomly assigned to CEE before age 60 seemed to derive mortality benefit over the long term.
Endogenous Sex-hormone Hormones (SHBG), and Exogenous Disruptors in Diabetes and Related Metabolic
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-as
Endogenous Sex-hormone Hormones (SHBG), and Exogenous Disruptors in Diabetes and Related Metabolic
sex- and gender- differences for the fundamental roles of sex-hormones, SHBG, and their environmental disruptors in cardiometabolic health are therefore crucia
Sex Differences of Endogenous Sex Hormones and Risk of Type 2 Diabetes
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
Endogenous Sex-hormone Hormones (SHBG), and Exogenous Disruptors in Diabetes and Related Metabolic
evaluating the association of plasma levels of testosterone, sex hormone–binding globulin (SHBG), and estradiol with risk of type 2 diabetes.
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
Menopausal hormone therapy continues in clinical use but questions remain
regarding its risks and benefits for chronic disease prevention.
Commentary: Is there a role for diabetes-specific nutrition formulas as meal replacements in type 2
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
A comprehensive, integrated overview of findings from the 2Women’s Health Initiative (WHI) hormone
liquid meal replacements replacing 1-2 meals per day or all meals (TDR) may have cardiometabolic advantages over traditional weight loss diets in overweight and obese adults with type 2 diabetes, with DNSFs potentially providing even greater benefits for glycemic control compared to standard formulas.
Original Reports Selected
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
Despite significant advances in DNAm-based deconvolution, references at the population level are needed for clinical and research interpretation of these additional immune layers. Here we aim to provide some references for immune populations in a group of multi-ethnic post-menopausal American women.
Genome-wide association analysis identifies ancestry-specific genetic variation associated with...
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
We present a well-phenotyped, densely genotyped, multi-ancestry resource to study gene-drug interactions, uncover novel variation associated with response to common glucose-lowering medications and provide insight into mechanisms of action of type 2 diabetes-related variation.
Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Pp Women
Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative usin
Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Pp Women
We use WHI observational data for further insight into the chronic disease implications of adopting this type of low-fat dietary pattern.
Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women...
Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women...
Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Pp Women
We sought to investigate the potential association between a personal history of being born preterm and risk for type 2 diabetes in a racially and ethnically diverse population.
Weight change and diabetes incidence: findings from a national cohort of US adults
Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women...
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance
Increase in BMI in the US that occurred during the 80s may portend an increase in the incidence of non-insulin-dependent diabetes mellitus with important public health consequences in future years.
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance
Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women...
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance
Diet and/or exercise interventions led to a significant decrease in the incidence of diabetes over a 6-year period among those with IGT.
Our work on protein intake featured as a cover story in the August issue of diabetes care
Our work on protein intake featured as a cover story in the August issue of diabetes care
Our work on protein intake featured as a cover story in the August issue of diabetes care
Good protein sources are important for#diabetes#body weight or perhaps even #planetary health
First prospective study linking dietary glycemic load to coronary risk
Our work on protein intake featured as a cover story in the August issue of diabetes care
Our work on protein intake featured as a cover story in the August issue of diabetes care
A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women
First orginal research report linking dietary factors to inflammation in humans
Our work on protein intake featured as a cover story in the August issue of diabetes care
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
First prospective study comprehensively assess circulation sex steroids, sex hormones binding globulin, and diabetes risk
Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men
First prospective study identifying SHBG gene, SHBG proteina causal predictor for type 2 diabetes in white men and white women
Birth Weight, Bio-mediators, and Diabetes Risk Later in Life
Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study
Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men
In this prospective study of women in the USA, we confirmed that LBW was significantly associated with increased type 2 diabetes risk later in life. We found that insulin resistance mediated a considerable amount of the total effect on type 2 diabetes risk due to LBW. This effect was further mediated by low SHBG concentration, elevated blood E-selectin level, and increased systolic blood pressure.s.
Recent Report
Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue
The role of SNRK in insulin signaling in white (WAT) and brown adipose tissue (BAT)
Sex Differences in Hypertension and Stroke Risk in the REGARDS Study A Longitudinal Cohort Study
Sex Differences in Hypertension and Stroke Risk in the REGARDS Study A Longitudinal Cohort Study
Relationship Between Dietary Magnesium Intake and Incident Heart Failure Among Older Women: The WHI
The association between magnesium intake and heart failure in a multiracial cohort of women
Metabolic signatures associated with Western and Prudent dietary patterns in women
Assess the association of 2 derived dietary pattern scores with serum metabolites and identify metabolic pathways associated with the metabolites
Lipoprotein(a) levels and risk of abdominal aortic aneurysm in the Women’s Health Initiative
There was no association between Lp(a) level and risk of 6 AAA in the Women’s Health Initiative
Micoronutrient Supplementation to Reduce Cardiovascular Risk
Provide a comprehensive and most up-to-date evidence-based map that systematically quantifies the impact of micronutrients on CVD outcomes.